Mayo Clinic’s Native American Pathway Program (NAPP) is designed to recruit health care professionals of the future and support patient care for American Indian Tribes and Alaska Native groups. The program helps undergraduate and post-baccalaureate students who are members of, or a descendant of an enrolled member of, a federally- or state-recognized American Indian Tribe or Alaska Native group develop the skills and tools they need to matriculate and persist in medical school. The scholars participate in a five-week virtual summer program that offers coaching for career and medical school readiness, career exploration, introduction to scientific research, and remote clinical observation. The NAPP curriculum utilizes culturally resonant practices and is delivered with regard to identity, resilience, and well-being. Instructors come from many backgrounds and include professionals who are tribal members and tribal elders. Following the summer program, scholars receive MCAT preparation through The Princeton Review including 66 hours of instruction, practice tests, books and resources, and hotline assistance. Long-term mentorship with a Mayo Clinic physician helps ensure that scholars are well-supported in their journey to medical school.