The National Native American Youth Initiative (NNAYI) is an intense enrichment program funded by the Association of American Indian Physicians and the Front Line Indigenous Partnership program (FLIP) based at the Brigham and Women’s Hospital (BWH) Department of Emergency Medicine and the Harvard Humanitarian Initiative. NNAYI is designed to prepare American Indian/Alaska Native (AI/AN) high school students to remain in the academic pipeline and pursue a career in the health professions and/or biomedical research. NNAYI’s curriculum is presented in lectures, interactive workshops, and field trips. Students will learn about various health professions, college and medical school admission processes, financial aid resources, and healthcare issues affecting AI/AN communities. Students will also network with AI/AN health professionals and learn about mentoring programs with AAIP member physicians.